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M9480556.TXT
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1994-08-20
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Document 0556
DOCN M9480556
TI [A synthetic peptide-based immunoenzyme test system for the joint
detection of human retrovirus (HTLV-1 and HIV-1) antibodies]
DT 9410
AU Rasuli AM; Klepikov NN; Gurtsevich VE; Andreev SM; Meshcheriakova DV;
Rasuli ShM
SO Gematol Transfuziol. 1993 May;38(5):36-9. Unique Identifier : AIDSLINE
MED/94307568
AB The study was made to develop an immunodiagnostic test system based on
synthetic peptides able to detect in the same assay the total
concentration of heterospecific antibodies against human retroviruses
HTLV-1 and HIV-1. Three panels of reference-sera contained antibodies to
HTLV-1 (70 specimens), HIV-1 (50 and 16 specimens) and 4 synthetic
peptides corresponding to protein fragments p19 gag and gp46 env HTLV-1,
gp120 and gp41 env HIV-1. Immune reactivity of the peptides with
reference sera was measured in the immunoassay. It is established that
relevant peptides mimic immunodominant B-epitopes of structural proteins
HTLV-1 and HIV-1 and are recognized specifically by relevant antiviral
antibodies. The enzyme immunoassay test system has been designed using a
peptide combination in a single antigen complex. The system showed high
diagnostic sensitivity.
DE Antibodies, Heterophile/*BLOOD Antigenic Determinants Comparative
Study English Abstract Human HIV Antibodies/*BLOOD HIV-1/*IMMUNOLOGY
HTLV-I Antibodies/*BLOOD *Immunoenzyme Techniques Peptide
Fragments/*DIAGNOSTIC USE/IMMUNOLOGY Reference Values Sensitivity and
Specificity JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).